Determination of serum plasminogen activator inhibitor -1 and homocysteine concentrations of Diabetes mellitus patients type 2 in Tikrit city population-Iraq.

الملخص

Type -2 diabetes mellitus is usually preceded by pre diabetes, in which levels of blood glucose are above normal but not high enough yet for a diagnosis of diabetes. The study aimed to measure the concentration of serum plasminogen activator inhibitor -1 and homocysteine concentration. This study was achieved by collecting 90 subjects who participate in the study, 35 patients diagnosed with type -2 Diabetes mellitus and obese, while 35 patients diagnosed with obese only and 20 healthy subjects as Control. The study was carried out in Salah-Aldin Hospital in Salah –Aldin governorate from beginning of March to end of June 2019. Serum homocysteine and plasminogen activator inhibitors (PAI-1) were measured by using human Elisa Kits manufactured by Bioassay Technology Laboratory company- China.There is elevation in body mass index in obese patients with DMT2, (G1), patients with obesity only, (G2), as compare with control group. Also, there was an elevation in serum homocysteine, (Hcy) in obese DMT2 as compare with obese patient and control healthy subjects, (P ≤ 0.01). Moreover,  the present study found a significant elevation in serum PA-1 concentration in obese DMT2 patients and in obese as compare with normal healthy control subjects.